Tirzepatide – Safety Information

Important Safety Information
Do not use Tirzepatide if you have been diagnosed with:

  • Diabetic ketoacidosis

  • Type 1 diabetes

  • Diabetic retinopathy

  • Kidney disease

  • Multiple endocrine neoplasia syndrome type 2 (MEN 2)

  • Thyroid cancer

  • Pancreatitis

Some side effects may occur but typically improve as your body adapts. Gastrointestinal symptoms may increase temporarily when your dose is raised but often lessen over time. If you experience any concerning effects, contact your healthcare provider—they can suggest ways to manage side effects. You may also reach out to us with any questions regarding your treatment or symptoms.

More Common Side Effects

  • Acid or sour stomach

  • Belching

  • Constipation

  • Diarrhea

  • Stomach discomfort or upset

  • Abdominal pain

  • Low blood sugar (hypoglycemia)

  • Injection site reactions

  • Gallbladder issues

  • Allergic reactions

Other side effects may also occur. Contact your healthcare provider if you experience anything unusual.

For medical advice about side effects or to report adverse effects, call the FDA at 1-800-FDA-1088.

Zepbound® Safety Information

Zepbound® (tirzepatide) is a prescription injectable for adults with obesity or excess weight and weight-related health concerns. It should be used alongside a reduced-calorie diet and increased physical activity.

Important Usage Information

  • Do not combine Zepbound® with other tirzepatide products or GLP-1 receptor agonists.

  • Safety with other weight-loss medications, including prescription, OTC, or herbal products, is unknown.

  • Safety in individuals with a history of pancreatitis or under 18 years old is unknown.

Warnings

  • May increase the risk of thyroid tumors, including thyroid cancer. Contact your doctor if you notice a lump in your neck, hoarseness, difficulty swallowing, or shortness of breath.

  • Do not use Zepbound® if:

    • You or a family member have medullary thyroid carcinoma (MTC)

    • You have MEN 2

    • You are allergic to tirzepatide or any ingredient

Serious Side Effects

  • Severe stomach issues, kidney complications, gallbladder disease, pancreatitis

  • Severe allergic reactions (swelling, trouble breathing, rashes, dizziness, fast heartbeat)

  • Low blood sugar (especially if used with insulin or sulfonylureas)

  • Vision changes in diabetic patients

  • Depression or suicidal thoughts

Common Side Effects

  • Nausea, diarrhea, vomiting, constipation, abdominal pain, indigestion

  • Fatigue, injection site reactions, belching, heartburn, hair loss

Before Using Zepbound®
Inform your provider if:

  • You use diabetes medications

  • You use oral contraceptives

  • You have pancreatic, kidney, or severe GI issues

  • You are pregnant, planning pregnancy, or breastfeeding

Pregnancy Exposure Registry
A registry monitors outcomes for women using Zepbound® during pregnancy. Ask your provider about enrolling or call Lilly at 1-800-LillyRx (1-800-545-5979).